For the love of Bufotenine
Bufotenine
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Bufotenine
Systematic (IUPAC) name
3-(2-dimethylaminoethyl)-1H-indol-5-ol
Clinical data
Legal status Schedule I (US)
Routes Parenteral
Identifiers
CAS number 487-93-4 Yes
ATC code None
PubChem CID 10257
IUPHAR ligand 144
DrugBank DB01445
ChemSpider 9839 Yes
KEGG C08299 Yes
ChEBI CHEBI:3210 Yes
ChEMBL CHEMBL416526 Yes
Synonyms N,N-dimethyl-5-hydroxytryptamine, 5-hydroxy-dimethyltryptamine, Bufotenine, cebilcin
Chemical data
Formula C12H16N2O
Mol. mass 204.268 g/mol
SMILES[show]
InChI[show]
Physical data
Melt. point 146–147 °C (295–297 °F)
Boiling point 320 °C (608 °F)
Bufotenin (also known as Bufotenine and cebilcin), or 5-hydroxy-N,N-dimethyltryptamine (5-OH-DMT), is a tryptamine related to the neurotransmitter serotonin. It is an alkaloid found in the skin of some species of toads; in mushrooms, higher plants, and mammals.[1]
The name Bufotenine originates from the Bufo genus of toads, which includes several species of psychoactive toads, most notably Bufo alvarius, that secrete bufotoxins from their parotoid glands.[2] Bufotenine is similar in chemical structure to the psychedelics psilocin (4-HO-DMT), 5-MeO-DMT, and DMT, chemicals which also occur in some of the same fungus, plant, and animal species as Bufotenine. The psychoactivity of Bufotenine has been disputed, though recent studies suggest it is similar in nature to 5-MeO-DMT.
Over the years Bufotenine really got a bad reputation due misinformation and contradictions spread across the Internet. I am hoping to correct this. I have read countless articles, blogs and forums where the misinformed state that Bufotenine is simply not worth the effort. Nothing can be further from the truth. Ignorant assholes! It is true that Bufotenine is a wild beast, but once you have formed a special relationship with bufo, it is simply the most incredible experience. Bufotenine is similar in chemical structure to psilocybin, but the experience is way different and far more visual. I have found it to be one of the most visual substances and it is my favorite green angel.
You don't choose Bufotenine. The Bufo spirit chooses you. She either likes you or she hates you. If she hates you, she will reject you and the next day you will tell the world what a waste of time Bufotenine is. If she likes you, she'll be gentle and she'll treat you with kindness...and once that spiritual connection is made, you are married to her for life.
So why the bad reputation? I believe there are many reasons. The most abundant source of Bufotenine comes from Anadenanthera Colubrina aka. as Cebil Seeds. A similar plant Anadenanthera Peregrine; Yopo also contains high amounts of Bufotenine, along with other alkaloids like dmt. Anadenanthera Colubrina contains more Bufotenine than Anadenanthera Peregrina and its also cheaper. The seeds can contain up to 10% of Bufotenine. I have read about many people complaining that their vendors sold them seeds that weren't fresh and therefor the seed were not as potent as they had expected. I am somewhat skeptic. I have used seeds that were more than a year old without any loss in potency. My suspicion is that these people didn't freebase their seeds properly. Freebasing is everything and has to be done correctly. Most people also use Calcium Hydroxide to freebase or make snuffs. Calcium Hydroxide (slaked lime) is a very powerful basing agent but can also destroy or break down Bufotenine. I only use Sodium Carbonate for freebasing.
Cebil (Vilca) or Yopo are often processed into snuffs by de shelling the seeds, roasting it and then mixing it with Calcium Hydroxide and water. The mixture is intimately mixed and then allowed to stand for a few hours to freebase before it is dried and powdered. In the beginning I tried the snuff a few times, but I was very disappointed. The results were never consistent (even snuff from the same batch). Snorting a gram of powdered seed and lime mix felt like a mixture of sand and razor blades grinding up the nose. It was incredibly painful and my nose was on fire for the whole duration of the trip. I guess this is the part that puts most people off Bufotenine. Although the snuff was incredibly visionary and overall a good experience. I didn't like using bufo intranasally, so I started exploring other ways.
Rectal Bufotenine Administration route: From what I read this is a good way of administering bufo with none of the usual nasty side effects. I cannot imagine anything going up where there is a huge sign saying "Exit Only". Needless to say I didn't bother to explore this route, but feel free to experiment. Different strokes for different folks I guess.
I ordered some more Anadenanthera Colubrina today from tranceplants seed today because my Bufotenine extract is running low.
What I like about Bufotenine is that as long as I do it once a week I don't seem to build up a tolerance. Although every experience is unique it remains as awesome and spectacular as the first time. Every time blows my mind. I prefer the short duration as oposed to many other substances. I do not want to wonder "Oh my God, when is this going to stop". It is a true visionary and mind altering experience but I never feel out of control or incapacitated. If I choose I can get up and do something else.
My research led me to believe there are only two viable options for using Bufotenine. Bufotenine can either be taken orally or be smoked. The latter requires a good extraction method. This is where things often go wrong. There are so many unverified or contradictory extraction teks, many are confusing and people often report back that some of these methods simply don't work, yields are low and effects are minimal. Without a good extraction tek your Bufotenine is worthless. The good news is I found an extraction tek that I am very happy with and I will list both teks for making oral Bufotenine and smokable Bufo. I am in no way taking credit for this work. It is not my own work and credit goes to pioneers like 69ron and others. Just follow the links at the top of the page. Enjoy :)
From Wikipedia, the free encyclopedia
Jump to: navigation, search
Bufotenine
Systematic (IUPAC) name
3-(2-dimethylaminoethyl)-1H-indol-5-ol
Clinical data
Legal status Schedule I (US)
Routes Parenteral
Identifiers
CAS number 487-93-4 Yes
ATC code None
PubChem CID 10257
IUPHAR ligand 144
DrugBank DB01445
ChemSpider 9839 Yes
KEGG C08299 Yes
ChEBI CHEBI:3210 Yes
ChEMBL CHEMBL416526 Yes
Synonyms N,N-dimethyl-5-hydroxytryptamine, 5-hydroxy-dimethyltryptamine, Bufotenine, cebilcin
Chemical data
Formula C12H16N2O
Mol. mass 204.268 g/mol
SMILES[show]
InChI[show]
Physical data
Melt. point 146–147 °C (295–297 °F)
Boiling point 320 °C (608 °F)
Bufotenin (also known as Bufotenine and cebilcin), or 5-hydroxy-N,N-dimethyltryptamine (5-OH-DMT), is a tryptamine related to the neurotransmitter serotonin. It is an alkaloid found in the skin of some species of toads; in mushrooms, higher plants, and mammals.[1]
The name Bufotenine originates from the Bufo genus of toads, which includes several species of psychoactive toads, most notably Bufo alvarius, that secrete bufotoxins from their parotoid glands.[2] Bufotenine is similar in chemical structure to the psychedelics psilocin (4-HO-DMT), 5-MeO-DMT, and DMT, chemicals which also occur in some of the same fungus, plant, and animal species as Bufotenine. The psychoactivity of Bufotenine has been disputed, though recent studies suggest it is similar in nature to 5-MeO-DMT.
Over the years Bufotenine really got a bad reputation due misinformation and contradictions spread across the Internet. I am hoping to correct this. I have read countless articles, blogs and forums where the misinformed state that Bufotenine is simply not worth the effort. Nothing can be further from the truth. Ignorant assholes! It is true that Bufotenine is a wild beast, but once you have formed a special relationship with bufo, it is simply the most incredible experience. Bufotenine is similar in chemical structure to psilocybin, but the experience is way different and far more visual. I have found it to be one of the most visual substances and it is my favorite green angel.
You don't choose Bufotenine. The Bufo spirit chooses you. She either likes you or she hates you. If she hates you, she will reject you and the next day you will tell the world what a waste of time Bufotenine is. If she likes you, she'll be gentle and she'll treat you with kindness...and once that spiritual connection is made, you are married to her for life.
So why the bad reputation? I believe there are many reasons. The most abundant source of Bufotenine comes from Anadenanthera Colubrina aka. as Cebil Seeds. A similar plant Anadenanthera Peregrine; Yopo also contains high amounts of Bufotenine, along with other alkaloids like dmt. Anadenanthera Colubrina contains more Bufotenine than Anadenanthera Peregrina and its also cheaper. The seeds can contain up to 10% of Bufotenine. I have read about many people complaining that their vendors sold them seeds that weren't fresh and therefor the seed were not as potent as they had expected. I am somewhat skeptic. I have used seeds that were more than a year old without any loss in potency. My suspicion is that these people didn't freebase their seeds properly. Freebasing is everything and has to be done correctly. Most people also use Calcium Hydroxide to freebase or make snuffs. Calcium Hydroxide (slaked lime) is a very powerful basing agent but can also destroy or break down Bufotenine. I only use Sodium Carbonate for freebasing.
Cebil (Vilca) or Yopo are often processed into snuffs by de shelling the seeds, roasting it and then mixing it with Calcium Hydroxide and water. The mixture is intimately mixed and then allowed to stand for a few hours to freebase before it is dried and powdered. In the beginning I tried the snuff a few times, but I was very disappointed. The results were never consistent (even snuff from the same batch). Snorting a gram of powdered seed and lime mix felt like a mixture of sand and razor blades grinding up the nose. It was incredibly painful and my nose was on fire for the whole duration of the trip. I guess this is the part that puts most people off Bufotenine. Although the snuff was incredibly visionary and overall a good experience. I didn't like using bufo intranasally, so I started exploring other ways.
Rectal Bufotenine Administration route: From what I read this is a good way of administering bufo with none of the usual nasty side effects. I cannot imagine anything going up where there is a huge sign saying "Exit Only". Needless to say I didn't bother to explore this route, but feel free to experiment. Different strokes for different folks I guess.
I ordered some more Anadenanthera Colubrina today from tranceplants seed today because my Bufotenine extract is running low.
What I like about Bufotenine is that as long as I do it once a week I don't seem to build up a tolerance. Although every experience is unique it remains as awesome and spectacular as the first time. Every time blows my mind. I prefer the short duration as oposed to many other substances. I do not want to wonder "Oh my God, when is this going to stop". It is a true visionary and mind altering experience but I never feel out of control or incapacitated. If I choose I can get up and do something else.
My research led me to believe there are only two viable options for using Bufotenine. Bufotenine can either be taken orally or be smoked. The latter requires a good extraction method. This is where things often go wrong. There are so many unverified or contradictory extraction teks, many are confusing and people often report back that some of these methods simply don't work, yields are low and effects are minimal. Without a good extraction tek your Bufotenine is worthless. The good news is I found an extraction tek that I am very happy with and I will list both teks for making oral Bufotenine and smokable Bufo. I am in no way taking credit for this work. It is not my own work and credit goes to pioneers like 69ron and others. Just follow the links at the top of the page. Enjoy :)